This book presents the field of closed-loop blood glucose control in a simple manner. This includes the hardware and “software” components that make up the control system. The hardware components involved the different types of glucose sensors available (invasive, minimally-invasive and non-invasive) and the different types of insulin. The software component represents the approaches that translate a given blood glucose reading to an appropriate insulin rate. Some of these approaches applied mathematical sciences to model the underlying system and formulate mathematical solutions. Examples are given on how mathematical models are formulated as well as the control algorithms that stem from mathematical exercises. This book describes from a functional level, the basic physiology of blood glucose regulation during fasting and meal. iT will serve as a useful reference to researches in this area of research to understand the fundamentals involved in blood glucose regulation and to gather most recent advancements in diabetes management.

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