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Epilepsy is a baffling and worrying diagnosis. This practical handbook answers over 200 real questions asked by parents of children with epilepsy. Their experiences and the authors’ expert answers give you the knowledge to help your child lead a happy, healthy and normal life.

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Motor Neurone Disease (MND) is a progressive disorder of the nervous system. Its effects on the body can be so severe that it eventually changes the lives of those affected and hence those of their families, friends and work colleagues. Motor Neurone Disease (MND) – the ‘at your fingertips’ guide is packed full of sensible advice. The expert authors address the physical and emotional upheaval that MND brings on, discussing its impact on the whole family, offering positive help and advice. The book provides up-to-date and medically accurate information on a whole range of topics from diagnosis and treatment to adapting to life with MND including mobility, feelings, sexual relationships and much more.

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Mitochondrial Genomics and Proteomics Protocols offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria. In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes such as apoptosis and cellular aging. This practical guide presents a wide spectrum of mitochondrial methods, each written by specialists with solid experience and intended for implementation by novice and expert researchers alike.

Part I introduces major experimental model systems and discusses their specific advantages and limitations for functional analysis of mitochondria. The concise overview of general properties of mitochondrial systems is supplemented by detailed protocols for cultivation of model organisms. Parts II-VI comprise a robust collection of protocols for studying different molecular aspects of mitochondrial functions including: genetics and microbiology, biochemistry, physiology, dynamics and morphology, and functional genomics. Emphasis is placed on new and emerging topics in mitochondrial study, such as the examination of apoptotic effects, fusion and fission of mitochondria, and proteome and transcriptome analysis.



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Pyrosequencing® Protocols presents detailed protocols for the multidisciplinary application of Pyrosequencing® technology, all written by world-renowned experts in the field. This comprehensive volume enables quick reference by collecting the primary applications for Pyrosequencing®, and supplementing each protocol with troubleshooting tips specific to that method.

Chapters 1 and 2 present an introductory overview of the origins of the Pyrosequencing® methodology and its key applications. Chapters 3 and 4 describe primer selection and the basic Pyrosequencing® technique, and Chapters 5-7 provide methods for improving throughput and decreasing cost. Detailed applications for Pyrosequencing® comprise Chapters 8-13, and the important aspects of data storage is discussed in Chapter 14. This comprehensive volume both highlights the versatility of and provides detailed protocols for the application of Pyrosequencing®.