The pharmaceutical industry worldwide is a rapidly burgeoning industry contributing to growth of gross domestic product and employment. Technological change in this field has been very rapid, with many new products being introduced. For this reason in part, health care budgets throughout the world have increased dramatically, eliciting growing pressures for cost containment. This book explores four important issues in pharmaceutical innovations: (1) the industry structure of pharmaceutical innovation; (2) incentives for correcting market failures in allocating resources for research and development; (3) competition and marketing; and (4) public evaluation of the benefits and costs of innovation. The lessons are applicable to countries all over the world, at all levels of economic development. By discussing existing evidence this book proposes incentive arrangements to accomplish social objectives.

Read the rest of this entry »

Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatment of CML and provides an authoritative and convenient summary of the latest progress in imatinib trials, the molecular monitoring of CML responses, and the engineering of new therapies to overcome resistance and improve patient care.

Designed for use either as a stand-alone guide or as a built-in part of the series’ audio packages, McGraw-Hill: Complete Medical Spanish offers health care professionals an enjoyable way to quickly acquire the skills and confidence they need to communicate with their Spanish-speaking patients. Each chapter focuses on a specific set of key terms and phrases and includes dozens of illustrations to help enhance understanding. Unlike other guides that make no distinction between levels of difficulty, this book introduces essential grammar concepts in a progressive manner.

Read the rest of this entry »

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials.
Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.


Read the rest of this entry »

Read the rest of this entry »

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity currently provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulates the hosts immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host. From the early stages of binding and receptors-mediated signalling, to new paradigms by which heat shock proteins are released into the circulation, to antigen processing and presentation, and finally to the immune response itself this book is a must read for graduate and postgraduates in the field of Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

This reference discusses best practices for the management of patients with cancers of the esophagus, stomach, colon, liver, and pancreas. Focusing on a wide variety of GI carcinomas by organ and tumor type, this source provides expert coverage of diagnostic, staging, and treatment procedures by seasoned oncologists and radiologists, and offers in-depth discussions of current research regarding tumor markers, molecular biology, and clinical presentation.

Written by top oculoplastic surgeons in the field, including Frank A. Nesi, MD, this atlas combines an innovative educational technique: line drawings that correspond to videoclips on DVD. The text’s distinguished authors have perfected the most frequently performed oculoplastic surgical techniques. Their atlas series is designed to instruct all ophthalmologists who wish to learn these techniques and thus enhance their income. This volume covers the latest in cosmetic facial surgery techniques including endoscopic foreheadplasty, direct eyebrow lift, rhytidectomy surgery, mid-face lift and facial cosmetic Botox. Mastery of these procedures is made easier by following the step-by-step illustrations that are complemented by videoclips on DVD. The study of the supporting anatomy, followed by clear cut guidelines with heavily illustrated techniques, offers a format which will allow the learner to gain the necessary understanding for achieving a more favorable result.

Read the rest of this entry »

Get problem-oriented and disease-specific guidance in treating STDs-in one quick-access source

Featuring the trusted, practical format of the CURRENT series, this authoritative, quick-access guide delivers a top-to-bottom overview of STDs commonly encountered in clinical practice. The book begins with an insightful introduction to the field that emphasizes the patient-doctor relationship, and then explores clinical problems with STDs in terms of diagnostic, management, and treatment considerations.

Features

• A-to-Z, up-to-the-minute coverage of common STDs-filled with crucial point-of-care guidelines
• A focus on prevention interventions, including counseling, in recognition of the need to change high-risk sexual behaviors
• Practical diagnostic algorithms that summarize key protocols and facilitate patient management
• Detailed, easy-to-locate treatment tables that list specific drugs (generic and trade names), doses, and schedules
• A thought-provoking final chapter that includes a brief discussion of the latest STD research, plus unresolved questions and future concerns
• Useful appendices that include diagnostic protocols, treatment tables, and websites for further information

Authoritative, on-the-spot information you can quickly apply to your practice - without sifting through pages of data

• An essential clinical companion for internists, family physicians, pediatricians, nurse practitioners, obstetricians-gynecologists, HIV care specialists, and other healthcare professionals who see patients with STDs
• Turn to any chapter on specific STDs, and you’ll find expert perspectives on biology, epidemiology, clinical manifestations, diagnosis, treatment, prevention, and issues related to special populations

Read the rest of this entry »

“This book is a comprehensive text on the all-important psychosocial aspects of cancer in children. Edited by an experienced psycho-oncologist and an equally experienced pediatric oncologist, the book brings together an international group of contributors composed of pediatric oncologists and psychologists/psycho-oncologists. This unique balance of contributors gives the book a focus on the real-life practical aspects of children undergoing treatment for cancer.

The book will help health care professionals who look after children and adolescents with cancer, in dealing with the difficult and complex problems that face the child, his siblings and his parents. It deals with critical issues such as the neuropsychological impact of treatment, (including bone marrow transplantation), pain, quality of life in survivors, palliative care, talking to children and their families about death, and providing support to the dying.

An important part of the book provides  tools for evaluation and methods of psychological intervention. It is thus a very practical work for psycho-oncologists, pediatric oncologists, pediatricians, psychologists, nurses, social workers and art therapists dealing with the problems that children with cancer have to confront.

• The only recent comprehensive book on the clinical approach to psychosocial problems of children with cancer 
  
• Includes evaluation tools and psychological intervention techniques
  
• Contributions from both pediatric oncologi sts and psycho-oncologists,
  highlight the team approach to the treatment of childhood cancers

“

Read the rest of this entry »